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Over a career in the Public Health Service that spanned five decades, he served as an editor of 17 reports of the Surgeon General on smoking and health, interim director of the Office on Smoking and Health, and advisor on smoking and health at the National Cancer Institute

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It can increase the chance of blood clotting, disrupt the gastrointestinal system, contribute to hardening of the arteries and heart attacks, 14 and lead to premature wrinkling